Job Details

Requisition Number 18-0230
Post Date 12/4/2018
Company Akcea
Title Sr. Director, Global Health Economics & Outcomes Research (HEOR)
Employment Type Full Time


Akcea Therapeutics is a biopharmaceutical company focused on developing and commercializing drugs to treat patients with serious rare diseases. Our priority is to bring important new therapeutics to patients in need. In order to do so, we must drive clinical program execution, understand patient and physician needs and work with regulators to gain global approval and market access to these new therapeutics. Akcea has a portfolio of development-stage drugs covering multiple targets and disease states using advanced antisense therapeutics.

Akcea was established by Ionis Pharmaceuticals in late 2014 and was listed on the NASDAQ stock exchange in July 2017 under the symbol “AKCA.” Akcea is a global company headquartered in Boston, MA with offices in Carlsbad, CA and across the EU and Canada. 


Sr. Director, Global Health Economics & Outcomes Research (HEOR)

The Sr. Director, Global Health Economics & Outcomes Research (HEOR) will play a critical and significant role in the growth of Akcea as an organization and in the successful commercialization of  Waylivra (volanesorsen), Tegsedi (inotersen), and our pipeline products. The Director will work at a global level to lead the development of HEOR research strategies and plans to support optimal market access for approved and pipeline products. In addition, they will support the development and submission of in-country Health Technology Assessment (HTA) and Pricing & Reimbursement (P&R) submissions.


The Sr. Director of HEOR will:

  • Develop global HEOR strategies including analyses of currently available data, and generate plans to fill identified gaps
  • Develop HEOR engagement strategies specific to payers and stakeholders in the US, Canada and Europe
  • Manage relationships with external consultants to ensure timely completion of high quality projects aligned to strategic objectives
  • Design, implement, and manage HEOR projects, including but not limited to:
    • retrospective database analyses
    • heath economic models
    • budget impact models
    • chart reviews
    • real world evidence
    • literature searches and systematic reviews
  • Support development and maintenance of global value dossiers
  • Identify appropriate data sources to support the projects described above
  • Conduct economic analyses and/or conduct detailed reviews of existing analyses
  • Work with KOLs to implement HEOR plans
  • Communicate study plans, study methods and results to internal teams
  • Present health outcomes research findings at scientific congresses and participate in the development and writing of manuscripts for publication in peer-reviewed journals
  • Build strong relationships with internal stakeholders and ensure continuous and consistent communication with key internal partners on HEOR projects
  • Represent HEOR on cross-functional internal teams
  • Remain current on HEOR data sources and analytical methods
  • Work with clinical development teams to identify appropriate trial endpoints for products in development
  • Work closely with US, European and Canadian commercial colleagues and external consultants to develop strategies specific to US, European or Canadian payers and stakeholders
  • Lead consultancy support in the development of in-country HTA and P&R dossiers
  • Identify appropriate US, European or Canadian data sources
  • Other projects and activities as assigned


  • Proven expertise in Health Economics / Outcomes Research
  • At least 5 years’ pharma/biotech experience with HEOR strategy and implementation in US, Canada, and Europe
  • Understanding market access and how HEOR evidence supports access decisions
  • Country and regional or global experience within a pharmaceutical company or consultancy
  • Rare disease, orphan or ultra-orphan product experience highly desirable
  • Life sciences degree; post-graduate degree preferred
  • Excellent verbal and written communication skills
  • Excellent analytical skills, including in-depth knowledge of health economic modelling
  • Experience in managing multiple projects across a variety of health outcomes methodologies and therapeutic areas
  • Solid understanding of epidemiology and biostatistics


  • Minimum masters degree, scientific or technical area 
  • Preferred to have advanced degree related to health economics and/or outcomes research
  • Fluent in English, written and oral


  • Travel required up to 30%

Position based in Boston, MA and is eligible for relocation.

Excellent salary and benefits package offered.

For more information on Akcea and to apply for this position, please visit our website: 

Reference #18-0230


Akcea Therapeutics, Inc. is proud to be an EEO employer.


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